Abstract: Objective To explore the epidemiological characteristics and drug resistance pattern of Salmonella infection in children. Methods The clinical features and the results of serotype and drug sensitive tests in hospitalized children having Salmonella strains detected in fecal samples were analyzed from February 2012 to September 2014. Results A total of 87 strains of salmonella were detected in the fecal samples of 2678 participants. Sixty-four strains (73.56%) were detected from May to September. Among 87 salmonella infectious cases (58 males and 29 females), 68 cases (78.16%) were under 2 years old. The major clinical symptoms were mucopurulent stool (65 cases, 74.17%) and fever (72 cases, 82.76%), and there also was rotavirus infection (10 cases, 11.49%). According to serological identification, there were 6 strains of Salmonella Buridan, 6 strains of Salmonella enteritidis, 5 strains of Salmonella typhimurium, 3 strains of Salmonella Arizona, 2 strains of Salmonella oranienburg, 2 strains of Salmonella Tsevie, and one strain each of New Laneige Salmonella, Salmonella derby, Salmonella agona, and Salmonella braenderup. Drug sensitivity tests showed that the rates of Salmonella resistant to cefazolin, cefuroxime, and gentamicin were 94.25%, 87.36%, and 87.36%, respectively. Moreover, 26 strains (29.89%) were multi-drug resistant. Conclusions Children under 2 years old are susceptible to Salmonella infection with males as majority. The common symptoms were mucopurulent stool and fever, and some may be accompanied with rotavirus infection. The common serotypes were Salmonella Buridan, Salmonella enteritidis, and Salmonella typhimurium. The salmonella are resistant to multiple antibiotics and even multi-drug resistant.